Dual-vector prodrug activator gene therapy using retroviral replicating vectors

Replicating Retroviral Vectors for Gene Therapy of Solid Tumors

Improved Therapeutic Efficacy of Cancer Gene Therapy using Retroviral Replicating Vectors Designed for Multiple Transgene Transduction

OF THE DISSERTATION .......................................................................................... ii COMMITTEE ................................................................................................................................ v TABLE OF CONTENTS ................................................................................................................ vi LIST OF ...

Beta thalassemia gene therapy using lentiviral vectors

Recent years, allogeneic bone marrow transplantation (BMT) has proved to be the successful cure for patients with thalassemia major, however this is restricted due to limited matched-related donor. Its complications include chronic graft-versus-host disease in 5-8% of patients. So, a molecular approach, such as gene therapy for direct normal beta globin gene transmission, seems quite promising ...

Retroviral Vectors for Cancer Gene Therapy.

Advances in molecular technologies have led to the discovery of many disease-related genetic mutations as well as elucidation of aberrant gene and protein expression patterns in several human diseases, including cancer. This information has driven the development of novel therapeutic strategies, such as the utilization of small molecules to target specific cellular pathways and the use of retro...

Retroviral vectors and gene therapy: An update

Gene therapy aims at treatment of diseases by transfer of genetic material into specific cells of a patient. So the transduction of appropriate target cell is critical. Retroviruses infect nearly every cell in the target population and become integrated in host cell genome for a stable expression. All retroviruses have only three structural genes gag, pol and env, except for lentiviruses where ...